Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
Ashwell, M.A., Lapierre, J.M., Brassard, C., Bresciano, K., Bull, C., Cornell-Kennon, S., Eathiraj, S., France, D.S., Hall, T., Hill, J., Kelleher, E., Khanapurkar, S., Kizer, D., Koerner, S., Link, J., Liu, Y., Makhija, S., Moussa, M., Namdev, N., Nguyen, K., Nicewonger, R., Palma, R., Szwaya, J., Tandon, M., Uppalapati, U., Vensel, D., Volak, L.P., Volckova, E., Westlund, N., Wu, H., Yang, R.Y., Chan, T.C.
J.Med.Chem.