PDB 4e90

PDB Links
Overview

PDB Information

PDB	4E90
Method	X-RAY DIFFRACTION
Host Organism
Gene Source	Homo sapiens
Primary Citation	Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. Claffey, M.M., Helal, C.J., Verhoest, P.R., Kang, Z., Fors, K.S., Jung, S., Zhong, J., Bundesmann, M.W., Hou, X., Lui, S., Kleiman, R.J., Vanase-Frawley, M., Schmidt, A.W., Menniti, F., Schmidt, C.J., Hoffman, W.E., Hajos, M., McDowell, L., O'Connor, R.E., Macdougall-Murphy, M., Fonseca, K.R., Becker, S.L., Nelson, F.R., Liras, S. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-03-20
Resolution	2.500
CATH Insert Date	28 Mar, 2013

PDB Images (5)

Image of CATH 4e90

4e90

PDB 4e90

Image of CATH 4e90A

4e90A

PDB Chain 4e90A

Image of CATH 4e90B

4e90B

PDB Chain 4e90B

Image of CATH 4e90A00

4e90A00

CATH Domain 4e90A00

Image of CATH 4e90B00

4e90B00

CATH Domain 4e90B00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	28 Mar, 2013	Chopped
B	28 Mar, 2013	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4e90A00	10 Apr, 2013	1.10.1300.10	Assigned
4e90B00	10 Apr, 2013	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O76083	PDE9A_HUMAN	Homo sapiens	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
O76083	PDE9A_HUMAN	Homo sapiens	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A