PDB 4e5w

PDB Links
Overview

PDB Information

PDB	4E5W
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors. Kulagowski, J.J., Blair, W., Bull, R.J., Chang, C., Deshmukh, G., Dyke, H.J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Harrison, T.K., Hewitt, P.R., Liimatta, M., Hurley, C.A., Johnson, A., Johnson, T., Kenny, J.R., Bir Kohli, P., Maxey, R.J., Mendonca, R., Mortara, K., Murray, J., Narukulla, R., Shia, S., Steffek, M., Ubhayakar, S., Ultsch, M., van Abbema, A., Ward, S.I., Waszkowycz, B., Zak, M. J.Med.Chem.
Header	Transferase/Transferase Inhibitor
Released	2012-03-14
Resolution	1.860
CATH Insert Date	03 Jun, 2012

PDB Images (7)

Image of CATH 4e5w

4e5w

PDB 4e5w

Image of CATH 4e5wA

4e5wA

PDB Chain 4e5wA

Image of CATH 4e5wB

4e5wB

PDB Chain 4e5wB

Image of CATH 4e5wA01

4e5wA01

CATH Domain 4e5wA01

Image of CATH 4e5wA02

4e5wA02

CATH Domain 4e5wA02

Image of CATH 4e5wB01

4e5wB01

CATH Domain 4e5wB01

Image of CATH 4e5wB02

4e5wB02

CATH Domain 4e5wB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	03 Jun, 2012	Chopped
B	03 Jun, 2012	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4e5wA01	08 Jun, 2012	3.30.200.20	Assigned
4e5wA02	08 Jun, 2012	1.10.510.10	Assigned
4e5wB01	08 Jun, 2012	3.30.200.20	Assigned
4e5wB02	08 Jun, 2012	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P23458	JAK1_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK1
P23458	JAK1_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK1