PDB 4e4n

PDB Links
Overview

PDB Information

PDB	4E4N
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors. Kulagowski, J.J., Blair, W., Bull, R.J., Chang, C., Deshmukh, G., Dyke, H.J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Harrison, T.K., Hewitt, P.R., Liimatta, M., Hurley, C.A., Johnson, A., Johnson, T., Kenny, J.R., Bir Kohli, P., Maxey, R.J., Mendonca, R., Mortara, K., Murray, J., Narukulla, R., Shia, S., Steffek, M., Ubhayakar, S., Ultsch, M., van Abbema, A., Ward, S.I., Waszkowycz, B., Zak, M. J.Med.Chem.
Header	Transferase/Transferase Inhibitor
Released	2012-03-13
Resolution	1.900
CATH Insert Date	03 Jun, 2012

PDB Images (7)

Image of CATH 4e4n

4e4n

PDB 4e4n

Image of CATH 4e4nA

4e4nA

PDB Chain 4e4nA

Image of CATH 4e4nB

4e4nB

PDB Chain 4e4nB

Image of CATH 4e4nA01

4e4nA01

CATH Domain 4e4nA01

Image of CATH 4e4nA02

4e4nA02

CATH Domain 4e4nA02

Image of CATH 4e4nB01

4e4nB01

CATH Domain 4e4nB01

Image of CATH 4e4nB02

4e4nB02

CATH Domain 4e4nB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	03 Jun, 2012	Chopped
B	03 Jun, 2012	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4e4nA01	08 Jun, 2012	3.30.200.20	Assigned
4e4nA02	08 Jun, 2012	1.10.510.10	Assigned
4e4nB01	08 Jun, 2012	3.30.200.20	Assigned
4e4nB02	08 Jun, 2012	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P23458	JAK1_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK1
P23458	JAK1_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK1