PDB 4dmx

PDB Information

PDB4DMX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
Dossetter, A.G., Beeley, H., Bowyer, J., Cook, C.R., Crawford, J.J., Finlayson, J.E., Heron, N.M., Heyes, C., Highton, A.J., Hudson, J.A., Jestel, A., Kenny, P.W., Krapp, S., Martin, S., MacFaul, P.A., McGuire, T.M., Gutierrez, P.M., Morley, A.D., Morris, J.J., Page, K.M., Ribeiro, L.R., Sawney, H., Steinbacher, S., Smith, C., Vickers, M.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-02-08
Resolution1.700
CATH Insert Date04 Nov, 2012

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
4dmxA00 10 Nov, 2012 3.90.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P43235 CATK_HUMAN Homo sapiens Cathepsin K