PDB 4dff

PDB Information

PDB4DFF
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Ho, G.D., Michael Seganish, W., Bercovici, A., Tulshian, D., Greenlee, W.J., Van Rijn, R., Hruza, A., Xiao, L., Rindgen, D., Mullins, D., Guzzi, M., Zhang, X., Bleickardt, C., Hodgson, R.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-01-23
Resolution2.110
CATH Insert Date27 May, 2012

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 May, 2012 Chopped
B 28 May, 2012 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4dffA00 08 Feb, 2013 1.10.1300.10 Assigned
4dffB00 08 Feb, 2013 1.10.1300.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9Y233 PDE10_HUMAN Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233 PDE10_HUMAN Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A