PDB 4dbw

PDB Information

PDB4DBW
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17 beta-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
Liedtke, A.J., Adeniji, A.O., Chen, M., Byrns, M.C., Jin, Y., Christianson, D.W., Marnett, L.J., Penning, T.M.
J.Med.Chem.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2012-01-16
Resolution1.800
CATH Insert Date28 Mar, 2013

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2013 Chopped
B 28 Mar, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4dbwA00 10 Apr, 2013 3.20.20.100 Assigned
4dbwB00 10 Apr, 2013 3.20.20.100 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P42330 AK1C3_HUMAN Homo sapiens Aldo-keto reductase family 1 member C3
P42330 AK1C3_HUMAN Homo sapiens Aldo-keto reductase family 1 member C3