PDB Information

PDB4CQE
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Optimization of Diarylthiazole B-Raf Inhibitors: Identification of a Compound Endowed with High Oral Antitumor Activity, Mitigated Herg Inhibition, and Low Paradoxical Effect.
Pulici, M., Traquandi, G., Marchionni, C., Modugno, M., Lupi, R., Amboldi, N., Casale, E., Colombo, N., Corti, L., Fasolini, M., Gasparri, F., Pastori, W., Scolaro, A., Donati, D., Felder, E., Galvani, A., Isacchi, A., Pesenti, E., Ciomei, M.
Chemmedchem
HeaderTransferase
Released2014-02-14
Resolution2.300
CATH Insert Date21 Dec, 2014

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 22 Dec, 2014 Chopped
B 22 Dec, 2014 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4cqeA01 28 Dec, 2014 3.30.200.20 Assigned
4cqeA02 28 Dec, 2014 1.10.510.10 Assigned
4cqeB01 28 Dec, 2014 3.30.200.20 Assigned
4cqeB02 28 Dec, 2014 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P15056 BRAF_HUMAN Homo sapiens Serine/threonine-protein kinase B-raf
P15056 BRAF_HUMAN Homo sapiens Serine/threonine-protein kinase B-raf