PDB 4cfx

PDB Information

PDB4CFX
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI B
Gene SourceHOMO SAPIENS
Primary Citation
8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
Carbain, B., Paterson, D.J., Anscombe, E., Campbell-Dexter, A., Cano, C., Echalier, A., Endicott, J., Golding, B.T., Haggerty, K., Hardcastle, I.R., Jewsbury, P.J., Newell, D.R., Noble, M., Roche, C., Wang, L., Griffin, R.J.
J.Med.Chem.
HeaderCell Cycle
Released2013-11-19
Resolution3.500
CATH Insert Date21 Dec, 2014

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 22 Dec, 2014 Chopped
B 22 Dec, 2014 Chopped
C 22 Dec, 2014 Chopped
D 22 Dec, 2014 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4cfxA01 29 Dec, 2014 3.30.200.20 Assigned
4cfxA02 29 Dec, 2014 1.10.510.10 Assigned
4cfxB01 29 Dec, 2014 1.10.472.10 Assigned
4cfxB02 29 Dec, 2014 1.10.472.10 Assigned
4cfxC01 29 Dec, 2014 3.30.200.20 Assigned
4cfxC02 29 Dec, 2014 1.10.510.10 Assigned
4cfxD01 29 Dec, 2014 1.10.472.10 Assigned
4cfxD02 29 Dec, 2014 1.10.472.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P20248 CCNA2_HUMAN Homo sapiens Cyclin-A2
P24941 CDK2_HUMAN Homo sapiens Cyclin-dependent kinase 2
P24941 CDK2_HUMAN Homo sapiens Cyclin-dependent kinase 2
P20248 CCNA2_HUMAN Homo sapiens Cyclin-A2