PDB 4bfr

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PDB Links
Overview

PDB Information

PDB	4BFR
Method	X-RAY DIFFRACTION
Host Organism	SPODOPTERA FRUGIPERDA
Gene Source	MUS MUSCULUS
Primary Citation	Discovery and Optimization of Pyrimidone Indoline Amide Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. Certal, V., Carry, J.B., Halley, F., Virone-Oddos, A., Thompson, F., Filoche-Romme, B., El-Ahmad, Y., Karlsson, A., Charrier, V., Delorme, C., Rak, A., Abecassis, P., Amara, C., Vincent, L., Bonnevaux, H., Nicolas, J., Mathieu, M., Bertrand, T., Marquette, J., Michot, N., Benard, T., Perrin, M., Lemaitre, O., Guerif, S., Perron, S., Monget, S., Gruss-Leleu, F., Doerflinger, G., Guizani, H., Brollo, M., Delbarre, L., Bertin, L., Richepin, P., Loyau, V., Garcia-Echeverria, C., Lengauer, C., Schio, L. J.Med.Chem.
Header	Transferase
Released	2013-03-22
Resolution	2.800
CATH Insert Date	02 Feb, 2014

PDB Images (13)

Image of CATH 4bfr

4bfr

PDB 4bfr

Image of CATH 4bfrA

4bfrA

PDB Chain 4bfrA

Image of CATH 4bfrB

4bfrB

PDB Chain 4bfrB

Image of CATH 4bfrA01

4bfrA01

CATH Domain 4bfrA01

Image of CATH 4bfrA02

4bfrA02

CATH Domain 4bfrA02

Image of CATH 4bfrA03

4bfrA03

CATH Domain 4bfrA03

Image of CATH 4bfrA04

4bfrA04

CATH Domain 4bfrA04

Image of CATH 4bfrA05

4bfrA05

CATH Domain 4bfrA05

Image of CATH 4bfrB01

4bfrB01

CATH Domain 4bfrB01

Image of CATH 4bfrB02

4bfrB02

CATH Domain 4bfrB02

Image of CATH 4bfrB03

4bfrB03

CATH Domain 4bfrB03

Image of CATH 4bfrB04

4bfrB04

CATH Domain 4bfrB04

Image of CATH 4bfrB05

4bfrB05

CATH Domain 4bfrB05

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	03 Feb, 2014	Chopped
B	03 Feb, 2014	Chopped

CATH Domains (10)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4bfrA01	07 Mar, 2014	3.10.20.90	Assigned
4bfrA02	07 Mar, 2014	2.60.40.150	Assigned
4bfrA03	07 Mar, 2014	1.25.40.70	Assigned
4bfrA04	07 Mar, 2014	3.30.1010.10	Assigned
4bfrA05	07 Mar, 2014	1.10.1070.11	Assigned
4bfrB01	07 Mar, 2014	1.25.40.70	Assigned
4bfrB02	07 Mar, 2014	3.10.20.90	Assigned
4bfrB03	07 Mar, 2014	2.60.40.150	Assigned
4bfrB04	07 Mar, 2014	3.30.1010.10	Assigned
4bfrB05	07 Mar, 2014	1.10.1070.11	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q8BTI9	PK3CB_MOUSE	Mus musculus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Q8BTI9	PK3CB_MOUSE	Mus musculus	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform