PDB 4bbf

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Overview

PDB Information

PDB	4BBF
Method	X-RAY DIFFRACTION
Host Organism	SPODOPTERA FRUGIPERDA
Gene Source	HOMO SAPIENS
Primary Citation	Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors Forsyth, T., Kearney, P.C., Kim, B.G., Johnson, H.W.B., Aay, N., Arcalas, A., Brown, D.S., Chan, V., Chen, J., Du, H., Epshteyn, S., Galan, A.A., Huynh, T.P., Ibrahim, M.A., Kane, B., Koltun, E., Mann, G., Meyr, L.E., Lee, M.S., Lewis, G.L., Noguchi, R.T., Pack, M., Ridgway, B.H., Shi, X., Takeuchi, C.S., Zu, P., Leahy, J.W., Nuss, J.M., Aoyama, R., Engst, S., Gendreau, S.B., Kassees, R., Li, J., Lin, S.-H., Martini, J.-F., Stout, T., Tong, P., Woolfrey, J., Zhang, W., Yu, P. Bioorg.Med.Chem.Lett.
Header	Transferase
Released	2012-09-21
Resolution	2.000
CATH Insert Date	02 Dec, 2012

PDB Images (13)

Image of CATH 4bbf

4bbf

PDB 4bbf

Image of CATH 4bbfA

4bbfA

PDB Chain 4bbfA

Image of CATH 4bbfB

4bbfB

PDB Chain 4bbfB

Image of CATH 4bbfC

4bbfC

PDB Chain 4bbfC

Image of CATH 4bbfD

4bbfD

PDB Chain 4bbfD

Image of CATH 4bbfA01

4bbfA01

CATH Domain 4bbfA01

Image of CATH 4bbfA02

4bbfA02

CATH Domain 4bbfA02

Image of CATH 4bbfB01

4bbfB01

CATH Domain 4bbfB01

Image of CATH 4bbfB02

4bbfB02

CATH Domain 4bbfB02

Image of CATH 4bbfC01

4bbfC01

CATH Domain 4bbfC01

Image of CATH 4bbfC02

4bbfC02

CATH Domain 4bbfC02

Image of CATH 4bbfD01

4bbfD01

CATH Domain 4bbfD01

Image of CATH 4bbfD02

4bbfD02

CATH Domain 4bbfD02

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	31 Dec, 2012	Chopped
B	31 Dec, 2012	Chopped
C	31 Dec, 2012	Chopped
D	31 Dec, 2012	Chopped

CATH Domains (8)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4bbfA01	03 Jan, 2013	3.30.200.20	Assigned
4bbfA02	03 Jan, 2013	1.10.510.10	Assigned
4bbfB01	03 Jan, 2013	3.30.200.20	Assigned
4bbfB02	03 Jan, 2013	1.10.510.10	Assigned
4bbfC01	03 Jan, 2013	3.30.200.20	Assigned
4bbfC02	03 Jan, 2013	1.10.510.10	Assigned
4bbfD01	03 Jan, 2013	3.30.200.20	Assigned
4bbfD02	03 Jan, 2013	1.10.510.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2