PDB 3wyl

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Overview

PDB Information

PDB	3WYL
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. Kunitomo, J., Yoshikawa, M., Fushimi, M., Kawada, A., Quinn, J.F., Oki, H., Kokubo, H., Kondo, M., Nakashima, K., Kamiguchi, N., Suzuki, K., Kimura, H., Taniguchi, T. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-09-01
Resolution	2.680
CATH Insert Date	30 Nov, 2014

PDB Images (5)

Image of CATH 3wyl

3wyl

PDB 3wyl

Image of CATH 3wylA

3wylA

PDB Chain 3wylA

Image of CATH 3wylB

3wylB

PDB Chain 3wylB

Image of CATH 3wylA00

3wylA00

CATH Domain 3wylA00

Image of CATH 3wylB00

3wylB00

CATH Domain 3wylB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	01 Dec, 2014	Chopped
B	01 Dec, 2014	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3wylA00	03 Dec, 2014	1.10.1300.10	Assigned
3wylB00	03 Dec, 2014	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A