PDB 3v3m

PDB Information

PDB3V3M
MethodX-RAY DIFFRACTION
Host OrganismHomo sapiens
Gene SourceSARS coronavirus
Primary Citation
Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease.
Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S.A., Chase, P., Eggler, A., Dawson, E.S., Baez-Santos, Y.M., Tomar, S., Mielech, A.M., Baker, S.C., Lindsley, C.W., Hodder, P., Mesecar, A., Stauffer, S.R.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2011-12-13
Resolution1.960
CATH Insert Date27 Jan, 2013

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 28 Jan, 2013 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
3v3mA01 27 Sep, 2013 2.40.10.10 Assigned
3v3mA02 27 Sep, 2013 2.40.10.10 Assigned
3v3mA03 27 Sep, 2013 1.10.1840.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P0C6U8 R1A_CVHSA Severe acute respiratory syndrome-related coronavirus Replicase polyprotein 1a