PDB 3uuo

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Overview

PDB Information

PDB	3UUO
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia. Ho, G.D., Yang, S.W., Smotryski, J., Bercovici, A., Nechuta, T., Smith, E.M., McElroy, W., Tan, Z., Tulshian, D., McKittrick, B., Greenlee, W.J., Hruza, A., Xiao, L., Rindgen, D., Mullins, D., Guzzi, M., Zhang, X., Bleickardt, C., Hodgson, R. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2011-11-28
Resolution	2.110
CATH Insert Date	29 Jan, 2012

PDB Images (5)

Image of CATH 3uuo

3uuo

PDB 3uuo

Image of CATH 3uuoA

3uuoA

PDB Chain 3uuoA

Image of CATH 3uuoB

3uuoB

PDB Chain 3uuoB

Image of CATH 3uuoA00

3uuoA00

CATH Domain 3uuoA00

Image of CATH 3uuoB00

3uuoB00

CATH Domain 3uuoB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	30 Jan, 2012	Chopped
B	30 Jan, 2012	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3uuoA00	08 Feb, 2013	1.10.1300.10	Assigned
3uuoB00	08 Feb, 2013	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A