PDB 3thb

PDB Information

PDB3THB
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905).
Duffey, M.O., Vos, T.J., Adams, R., Alley, J., Anthony, J., Barrett, C., Bharathan, I., Bowman, D., Bump, N.J., Chau, R., Cullis, C., Driscoll, D.L., Elder, A., Forsyth, N., Frazer, J., Guo, J., Guo, L., Hyer, M.L., Janowick, D., Kulkarni, B., Lai, S.J., Lasky, K., Li, G., Li, J., Liao, D., Little, J., Peng, B., Qian, M.G., Reynolds, D.J., Rezaei, M., Scott, M.P., Sells, T.B., Shinde, V., Shi, Q.J., Sintchak, M.D., Soucy, F., Sprott, K.T., Stroud, S.G., Nestor, M., Visiers, I., Weatherhead, G., Ye, Y., D'Amore, N.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2011-08-18
Resolution2.500
CATH Insert Date27 Nov, 2011

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 29 Nov, 2011 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
3thbA01 01 Dec, 2011 3.30.200.20 Assigned
3thbA02 01 Dec, 2011 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P53350 PLK1_HUMAN Homo sapiens Serine/threonine-protein kinase PLK1