PDB 3srv

PDB Information

PDB3SRV
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Liddle, J., Atkinson, F.L., Barker, M.D., Carter, P.S., Curtis, N.R., Davis, R.P., Douault, C., Dickson, M.C., Elwes, D., Garton, N.S., Gray, M., Hayhow, T.G., Hobbs, C.I., Jones, E., Leach, S., Leavens, K., Lewis, H.D., McCleary, S., Neu, M., Patel, V.K., Preston, A.G., Ramirez-Molina, C., Shipley, T.J., Skone, P.A., Smithers, N., Somers, D.O., Walker, A.L., Watson, R.J., Weingarten, G.G.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2011-07-07
Resolution1.950
CATH Insert Date26 Sep, 2011

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Nov, 2011 Chopped
B 29 Nov, 2011 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3srvA01 01 Dec, 2011 3.30.200.20 Assigned
3srvA02 01 Dec, 2011 1.10.510.10 Assigned
3srvB01 01 Dec, 2011 3.30.200.20 Assigned
3srvB02 01 Dec, 2011 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43405 KSYK_HUMAN Homo sapiens Tyrosine-protein kinase SYK
P43405 KSYK_HUMAN Homo sapiens Tyrosine-protein kinase SYK