PDB 3sl8

PDB Links
Overview

PDB Information

PDB	3SL8
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2. Nankervis, J.L., Feil, S.C., Hancock, N.C., Zheng, Z., Ng, H.L., Morton, C.J., Holien, J.K., Ho, P.W., Frazzetto, M.M., Jennings, I.G., Manallack, D.T., Martin, T.J., Thompson, P.E., Parker, M.W. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2011-06-24
Resolution	2.600
CATH Insert Date	30 Oct, 2011

PDB Images (9)

Image of CATH 3sl8

3sl8

PDB 3sl8

Image of CATH 3sl8A

3sl8A

PDB Chain 3sl8A

Image of CATH 3sl8B

3sl8B

PDB Chain 3sl8B

Image of CATH 3sl8C

3sl8C

PDB Chain 3sl8C

Image of CATH 3sl8D

3sl8D

PDB Chain 3sl8D

Image of CATH 3sl8A00

3sl8A00

CATH Domain 3sl8A00

Image of CATH 3sl8B00

3sl8B00

CATH Domain 3sl8B00

Image of CATH 3sl8C00

3sl8C00

CATH Domain 3sl8C00

Image of CATH 3sl8D00

3sl8D00

CATH Domain 3sl8D00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	29 Nov, 2011	Chopped
B	29 Nov, 2011	Chopped
C	29 Nov, 2011	Chopped
D	29 Nov, 2011	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3sl8A00	25 Apr, 2013	1.10.1300.10	Assigned
3sl8B00	25 Apr, 2013	1.10.1300.10	Assigned
3sl8C00	25 Apr, 2013	1.10.1300.10	Assigned
3sl8D00	25 Apr, 2013	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D