PDB Information

PDB3SDI
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Blackburn, C., Barrett, C., Blank, J.L., Bruzzese, F.J., Bump, N., Dick, L.R., Fleming, P., Garcia, K., Hales, P., Hu, Z., Jones, M., Liu, J.X., Sappal, D.S., Sintchak, M.D., Tsu, C., Gigstad, K.M.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2011-06-09
Resolution2.650
CATH Insert Date17 Jun, 2012

PDB Images (57)

PDB Prints

PDB Chains (28)

Chain ID Date inserted into CATH CATH Status
1 18 Jun, 2012 Chopped
2 18 Jun, 2012 Chopped
A 18 Jun, 2012 Chopped
B 18 Jun, 2012 Chopped
C 18 Jun, 2012 Chopped
D 18 Jun, 2012 Chopped
E 18 Jun, 2012 Chopped
F 18 Jun, 2012 Chopped
G 18 Jun, 2012 Chopped
H 18 Jun, 2012 Chopped
I 18 Jun, 2012 Chopped
J 18 Jun, 2012 Chopped
K 18 Jun, 2012 Chopped
L 18 Jun, 2012 Chopped
M 18 Jun, 2012 Chopped
N 18 Jun, 2012 Chopped
O 18 Jun, 2012 Chopped
P 18 Jun, 2012 Chopped
Q 18 Jun, 2012 Chopped
R 18 Jun, 2012 Chopped
S 18 Jun, 2012 Chopped
T 18 Jun, 2012 Chopped
U 18 Jun, 2012 Chopped
V 18 Jun, 2012 Chopped
W 18 Jun, 2012 Chopped
X 18 Jun, 2012 Chopped
Y 18 Jun, 2012 Chopped
Z 18 Jun, 2012 Chopped

CATH Domains (28)

Domain ID Date inserted into CATH Superfamily CATH Status
3sdi100 26 Jun, 2012 3.60.20.10 Assigned
3sdi200 26 Jun, 2012 3.60.20.10 Assigned
3sdiA00 04 Feb, 2013 3.60.20.10 Assigned
3sdiB00 04 Feb, 2013 3.60.20.10 Assigned
3sdiC00 04 Feb, 2013 3.60.20.10 Assigned
3sdiD00 08 Feb, 2013 3.60.20.10 Assigned
3sdiE00 26 Jun, 2012 3.60.20.10 Assigned
3sdiF00 26 Jun, 2012 3.60.20.10 Assigned
3sdiG00 26 Jun, 2012 3.60.20.10 Assigned
3sdiH00 26 Jun, 2012 3.60.20.10 Assigned
3sdiI00 26 Jun, 2012 3.60.20.10 Assigned
3sdiJ00 26 Jun, 2012 3.60.20.10 Assigned
3sdiK00 26 Jun, 2012 3.60.20.10 Assigned
3sdiL00 26 Jun, 2012 3.60.20.10 Assigned
3sdiM00 26 Jun, 2012 3.60.20.10 Assigned
3sdiN00 26 Jun, 2012 3.60.20.10 Assigned
3sdiO00 04 Feb, 2013 3.60.20.10 Assigned
3sdiP00 04 Feb, 2013 3.60.20.10 Assigned
3sdiQ00 04 Feb, 2013 3.60.20.10 Assigned
3sdiR00 08 Feb, 2013 3.60.20.10 Assigned
3sdiS00 26 Jun, 2012 3.60.20.10 Assigned
3sdiT00 26 Jun, 2012 3.60.20.10 Assigned
3sdiU00 26 Jun, 2012 3.60.20.10 Assigned
3sdiV00 26 Jun, 2012 3.60.20.10 Assigned
3sdiW00 26 Jun, 2012 3.60.20.10 Assigned
3sdiX00 26 Jun, 2012 3.60.20.10 Assigned
3sdiY00 26 Jun, 2012 3.60.20.10 Assigned
3sdiZ00 26 Jun, 2012 3.60.20.10 Assigned

UniProtKB Entries (28)

Accession Gene ID Taxon Description
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P25043 PSB2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-2
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P25043 PSB2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-2
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5