PDB 3rtp

PDB Information

PDB3RTP
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bowers, S., Truong, A.P., Jeffrey Neitz, R., Hom, R.K., Sealy, J.M., Probst, G.D., Quincy, D., Peterson, B., Chan, W., Galemmo, R.A., Konradi, A.W., Sham, H.L., Toth, G., Pan, H., Lin, M., Yao, N., Artis, D.R., Zhang, H., Chen, L., Dryer, M., Samant, B., Zmolek, W., Wong, K., Lorentzen, C., Goldbach, E., Tonn, G., Quinn, K.P., Sauer, J.M., Wright, S., Powell, K., Ruslim, L., Ren, Z., Bard, F., Yednock, T.A., Griswold-Prenner, I.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2011-05-03
Resolution2.400
CATH Insert Date07 Jul, 2013

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
3rtpA01 08 Aug, 2013 3.30.200.20 Assigned
3rtpA02 08 Aug, 2013 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P53779 MK10_HUMAN Homo sapiens Mitogen-activated protein kinase 10