PDB 3rsx

PDB Information

PDB3RSX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1).
Cheng, Y., Judd, T.C., Bartberger, M.D., Brown, J., Chen, K., Fremeau, R.T., Hickman, D., Hitchcock, S.A., Jordan, B., Li, V., Lopez, P., Louie, S.W., Luo, Y., Michelsen, K., Nixey, T., Powers, T.S., Rattan, C., Sickmier, E.A., St Jean, D.J., Wahl, R.C., Wen, P.H., Wood, S.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2011-05-02
Resolution2.480
CATH Insert Date04 Sep, 2011

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Sep, 2011 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
3rsxA01 07 Sep, 2011 2.40.70.10 Assigned
3rsxA02 07 Sep, 2011 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1