PDB 3rjm

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Overview

PDB Information

PDB	3RJM
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Maillard, M.C., Brookfield, F.A., Courtney, S.M., Eustache, F.M., Gemkow, M.J., Handel, R.K., Johnson, L.C., Johnson, P.D., Kerry, M.A., Krieger, F., Meniconi, M., Munoz-Sanjuan, I., Palfrey, J.J., Park, H., Schaertl, S., Taylor, M.G., Weddell, D., Dominguez, C. Bioorg.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2011-04-15
Resolution	2.550
CATH Insert Date	26 Sep, 2011

PDB Images (11)

Image of CATH 3rjm

3rjm

PDB 3rjm

Image of CATH 3rjmA

3rjmA

PDB Chain 3rjmA

Image of CATH 3rjmB

3rjmB

PDB Chain 3rjmB

Image of CATH 3rjmC

3rjmC

PDB Chain 3rjmC

Image of CATH 3rjmD

3rjmD

PDB Chain 3rjmD

Image of CATH 3rjmE

3rjmE

PDB Chain 3rjmE

Image of CATH 3rjmF

3rjmF

PDB Chain 3rjmF

Image of CATH 3rjmA00

3rjmA00

CATH Domain 3rjmA00

Image of CATH 3rjmB00

3rjmB00

CATH Domain 3rjmB00

Image of CATH 3rjmC00

3rjmC00

CATH Domain 3rjmC00

Image of CATH 3rjmD00

3rjmD00

CATH Domain 3rjmD00

PDB Prints

PDB Chains (6)

Chain ID	Date inserted into CATH	CATH Status
A	29 Nov, 2011	Chopped
B	29 Nov, 2011	Chopped
C	29 Nov, 2011	Chopped
D	29 Nov, 2011	Chopped
E	29 Nov, 2011	Rejected
F	29 Nov, 2011	Rejected

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3rjmA00	01 Dec, 2011	3.40.50.1460	Assigned
3rjmB00	01 Dec, 2011	3.30.70.1470	Assigned
3rjmC00	01 Dec, 2011	3.40.50.1460	Assigned
3rjmD00	01 Dec, 2011	3.30.70.1470	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P42575	CASP2_HUMAN	Homo sapiens	Caspase-2
P42575	CASP2_HUMAN	Homo sapiens	Caspase-2
P42575	CASP2_HUMAN	Homo sapiens	Caspase-2
P42575	CASP2_HUMAN	Homo sapiens	Caspase-2