Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
Zehnder, L., Bennett, M., Meng, J., Huang, B., Ninkovic, S., Wang, F., Braganza, J., Tatlock, J., Jewell, T., Zhou, J.Z., Burke, B., Wang, J., Maegley, K., Mehta, P.P., Yin, M.J., Gajiwala, K.S., Hickey, M.J., Yamazaki, S., Smith, E., Kang, P., Sistla, A., Dovalsantos, E., Gehring, M.R., Kania, R., Wythes, M., Kung, P.P.
J.Med.Chem.