PDB Information

PDB3QPO
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceRattus norvegicus
Primary Citation
Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia.
Helal, C.J., Kang, Z., Hou, X., Pandit, J., Chappie, T.A., Humphrey, J.M., Marr, E.S., Fennell, K.F., Chenard, L.K., Fox, C., Schmidt, C.J., Williams, R.D., Chapin, D.S., Siuciak, J., Lebel, L., Menniti, F., Cianfrogna, J., Fonseca, K.R., Nelson, F.R., O'Connor, R., Macdougall, M., McDowell, L., Liras, S.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2011-02-14
Resolution1.800
CATH Insert Date19 Jun, 2011

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 20 Jun, 2011 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
3qpoA00 08 Feb, 2013 1.10.1300.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q9QYJ6 PDE10_RAT Rattus norvegicus cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A