PDB 3qaz

PDB Links
Overview

PDB Information

PDB	3QAZ
Method	X-RAY DIFFRACTION
Host Organism	Trichoplusia ni
Gene Source	Homo sapiens
Primary Citation	Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Levin, A.M., Bates, D.L., Ring, A.M., Krieg, C., Lin, J.T., Su, L., Moraga, I., Raeber, M.E., Bowman, G.R., Novick, P., Pande, V.S., Fathman, C.G., Boyman, O., Garcia, K.C. Nature
Header	Signaling Protein/Cytokine
Released	2011-01-12
Resolution	3.800
CATH Insert Date	27 May, 2012

PDB Images (97)

3qaz

PDB 3qaz

3qaza

PDB Chain 3qaza

3qazA

PDB Chain 3qazA

3qazb

PDB Chain 3qazb

3qazB

PDB Chain 3qazB

3qazc

PDB Chain 3qazc

3qazC

PDB Chain 3qazC

3qazd

PDB Chain 3qazd

3qazD

PDB Chain 3qazD

3qaze

PDB Chain 3qaze

3qazE

PDB Chain 3qazE

3qazf

PDB Chain 3qazf

3qazF

PDB Chain 3qazF

3qazg

PDB Chain 3qazg

3qazG

PDB Chain 3qazG

3qazh

PDB Chain 3qazh

3qazH

PDB Chain 3qazH

3qazi

PDB Chain 3qazi

3qazI

PDB Chain 3qazI

3qazj

PDB Chain 3qazj

3qazJ

PDB Chain 3qazJ

3qazK

PDB Chain 3qazK

3qazL

PDB Chain 3qazL

3qazM

PDB Chain 3qazM

3qazN

PDB Chain 3qazN

3qazO

PDB Chain 3qazO

3qazP

PDB Chain 3qazP

3qazQ

PDB Chain 3qazQ

3qazR

PDB Chain 3qazR

3qazS

PDB Chain 3qazS

3qazT

PDB Chain 3qazT

3qazU

PDB Chain 3qazU

3qazV

PDB Chain 3qazV

3qazW

PDB Chain 3qazW

3qazX

PDB Chain 3qazX

3qazY

PDB Chain 3qazY

3qazZ

PDB Chain 3qazZ

3qazA00

CATH Domain 3qazA00

3qaza01

CATH Domain 3qaza01

3qaza02

CATH Domain 3qaza02

3qazb00

CATH Domain 3qazb00

3qazB01

CATH Domain 3qazB01

3qazB02

CATH Domain 3qazB02

3qazc01

CATH Domain 3qazc01

3qazC01

CATH Domain 3qazC01

3qazc02

CATH Domain 3qazc02

3qazC02

CATH Domain 3qazC02

3qazD00

CATH Domain 3qazD00

3qazd01

CATH Domain 3qazd01

3qazd02

CATH Domain 3qazd02

3qaze00

CATH Domain 3qaze00

3qazE01

CATH Domain 3qazE01

3qazE02

CATH Domain 3qazE02

3qazf01

CATH Domain 3qazf01

3qazF01

CATH Domain 3qazF01

3qazf02

CATH Domain 3qazf02

3qazF02

CATH Domain 3qazF02

3qazG00

CATH Domain 3qazG00

3qazg01

CATH Domain 3qazg01

3qazg02

CATH Domain 3qazg02

3qazh00

CATH Domain 3qazh00

3qazH01

CATH Domain 3qazH01

3qazH02

CATH Domain 3qazH02

3qazi01

CATH Domain 3qazi01

3qazI01

CATH Domain 3qazI01

3qazi02

CATH Domain 3qazi02

3qazI02

CATH Domain 3qazI02

3qazJ00

CATH Domain 3qazJ00

3qazj01

CATH Domain 3qazj01

3qazj02

CATH Domain 3qazj02

3qazK01

CATH Domain 3qazK01

3qazK02

CATH Domain 3qazK02

3qazL01

CATH Domain 3qazL01

3qazL02

CATH Domain 3qazL02

3qazM00

CATH Domain 3qazM00

3qazN01

CATH Domain 3qazN01

3qazN02

CATH Domain 3qazN02

3qazO01

CATH Domain 3qazO01

3qazO02

CATH Domain 3qazO02

3qazP00

CATH Domain 3qazP00

3qazQ01

CATH Domain 3qazQ01

3qazQ02

CATH Domain 3qazQ02

3qazR01

CATH Domain 3qazR01

3qazR02

CATH Domain 3qazR02

3qazS00

CATH Domain 3qazS00

3qazT01

CATH Domain 3qazT01

3qazT02

CATH Domain 3qazT02

3qazU01

CATH Domain 3qazU01

3qazU02

CATH Domain 3qazU02

3qazV00

CATH Domain 3qazV00

3qazW01

CATH Domain 3qazW01

3qazW02

CATH Domain 3qazW02

3qazX01

CATH Domain 3qazX01

3qazX02

CATH Domain 3qazX02

3qazY00

CATH Domain 3qazY00

3qazZ01

CATH Domain 3qazZ01

3qazZ02

CATH Domain 3qazZ02

PDB Prints

PDB Chains (36)

Chain ID	Date inserted into CATH	CATH Status
a	28 May, 2012	Chopped
A	28 May, 2012	Chopped
b	28 May, 2012	Chopped
B	28 May, 2012	Chopped
c	28 May, 2012	Chopped
C	28 May, 2012	Chopped
d	28 May, 2012	Chopped
D	28 May, 2012	Chopped
e	28 May, 2012	Chopped
E	28 May, 2012	Chopped
f	28 May, 2012	Chopped
F	28 May, 2012	Chopped
g	28 May, 2012	Chopped
G	28 May, 2012	Chopped
h	28 May, 2012	Chopped
H	28 May, 2012	Chopped
i	28 May, 2012	Chopped
I	28 May, 2012	Chopped
j	28 May, 2012	Chopped
J	28 May, 2012	Chopped
K	28 May, 2012	Chopped
L	28 May, 2012	Chopped
M	28 May, 2012	Chopped
N	28 May, 2012	Chopped
O	28 May, 2012	Chopped
P	28 May, 2012	Chopped
Q	28 May, 2012	Chopped
R	28 May, 2012	Chopped
S	28 May, 2012	Chopped
T	28 May, 2012	Chopped
U	28 May, 2012	Chopped
V	28 May, 2012	Chopped
W	28 May, 2012	Chopped
X	28 May, 2012	Chopped
Y	28 May, 2012	Chopped
Z	28 May, 2012	Chopped

CATH Domains (60)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3qazA00	08 Jun, 2012	1.20.1250.10	Assigned
3qaza01	08 Jun, 2012	2.60.40.10	Assigned
3qaza02	08 Jun, 2012	2.60.40.10	Assigned
3qazb00	08 Jun, 2012	1.20.1250.10	Assigned
3qazB01	08 Jun, 2012	2.60.40.10	Assigned
3qazB02	08 Jun, 2012	2.60.40.10	Assigned
3qazc01	08 Jun, 2012	2.60.40.10	Assigned
3qazC01	08 Jun, 2012	2.60.40.10	Assigned
3qazc02	08 Jun, 2012	2.60.40.10	Assigned
3qazC02	08 Jun, 2012	2.60.40.10	Assigned
3qazD00	08 Jun, 2012	1.20.1250.10	Assigned
3qazd01	08 Jun, 2012	2.60.40.10	Assigned
3qazd02	08 Jun, 2012	2.60.40.10	Assigned
3qaze00	08 Jun, 2012	1.20.1250.10	Assigned
3qazE01	08 Jun, 2012	2.60.40.10	Assigned
3qazE02	08 Jun, 2012	2.60.40.10	Assigned
3qazf01	08 Jun, 2012	2.60.40.10	Assigned
3qazF01	08 Jun, 2012	2.60.40.10	Assigned
3qazf02	08 Jun, 2012	2.60.40.10	Assigned
3qazF02	08 Jun, 2012	2.60.40.10	Assigned
3qazG00	08 Jun, 2012	1.20.1250.10	Assigned
3qazg01	08 Jun, 2012	2.60.40.10	Assigned
3qazg02	08 Jun, 2012	2.60.40.10	Assigned
3qazh00	08 Jun, 2012	1.20.1250.10	Assigned
3qazH01	08 Jun, 2012	2.60.40.10	Assigned
3qazH02	08 Jun, 2012	2.60.40.10	Assigned
3qazi01	08 Jun, 2012	2.60.40.10	Assigned
3qazI01	08 Jun, 2012	2.60.40.10	Assigned
3qazi02	08 Jun, 2012	2.60.40.10	Assigned
3qazI02	08 Jun, 2012	2.60.40.10	Assigned
3qazJ00	08 Jun, 2012	1.20.1250.10	Assigned
3qazj01	08 Jun, 2012	2.60.40.10	Assigned
3qazj02	08 Jun, 2012	2.60.40.10	Assigned
3qazK01	08 Jun, 2012	2.60.40.10	Assigned
3qazK02	08 Jun, 2012	2.60.40.10	Assigned
3qazL01	08 Jun, 2012	2.60.40.10	Assigned
3qazL02	08 Jun, 2012	2.60.40.10	Assigned
3qazM00	08 Jun, 2012	1.20.1250.10	Assigned
3qazN01	08 Jun, 2012	2.60.40.10	Assigned
3qazN02	08 Jun, 2012	2.60.40.10	Assigned
3qazO01	08 Jun, 2012	2.60.40.10	Assigned
3qazO02	08 Jun, 2012	2.60.40.10	Assigned
3qazP00	08 Jun, 2012	1.20.1250.10	Assigned
3qazQ01	08 Jun, 2012	2.60.40.10	Assigned
3qazQ02	08 Jun, 2012	2.60.40.10	Assigned
3qazR01	08 Jun, 2012	2.60.40.10	Assigned
3qazR02	08 Jun, 2012	2.60.40.10	Assigned
3qazS00	08 Jun, 2012	1.20.1250.10	Assigned
3qazT01	08 Jun, 2012	2.60.40.10	Assigned
3qazT02	08 Jun, 2012	2.60.40.10	Assigned
3qazU01	08 Jun, 2012	2.60.40.10	Assigned
3qazU02	08 Jun, 2012	2.60.40.10	Assigned
3qazV00	08 Jun, 2012	1.20.1250.10	Assigned
3qazW01	08 Jun, 2012	2.60.40.10	Assigned
3qazW02	08 Jun, 2012	2.60.40.10	Assigned
3qazX01	08 Jun, 2012	2.60.40.10	Assigned
3qazX02	08 Jun, 2012	2.60.40.10	Assigned
3qazY00	08 Jun, 2012	1.20.1250.10	Assigned
3qazZ01	08 Jun, 2012	2.60.40.10	Assigned
3qazZ02	08 Jun, 2012	2.60.40.10	Assigned

UniProtKB Entries (36)

Accession	Gene ID	Taxon	Description
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P31785	IL2RG_HUMAN	Homo sapiens	Cytokine receptor common subunit gamma
P60568	IL2_HUMAN	Homo sapiens	Interleukin-2
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta
P14784	IL2RB_HUMAN	Homo sapiens	Interleukin-2 receptor subunit beta