PDB 3pi5

PDB Links
Overview

PDB Information

PDB	3PI5
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Rueeger, H., Rondeau, J.M., McCarthy, C., Mobitz, H., Tintelnot-Blomley, M., Neumann, U., Desrayaud, S. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2010-11-05
Resolution	2.400
CATH Insert Date	27 Mar, 2011

PDB Images (10)

Image of CATH 3pi5

3pi5

PDB 3pi5

Image of CATH 3pi5A

3pi5A

PDB Chain 3pi5A

Image of CATH 3pi5B

3pi5B

PDB Chain 3pi5B

Image of CATH 3pi5C

3pi5C

PDB Chain 3pi5C

Image of CATH 3pi5A01

3pi5A01

CATH Domain 3pi5A01

Image of CATH 3pi5A02

3pi5A02

CATH Domain 3pi5A02

Image of CATH 3pi5B01

3pi5B01

CATH Domain 3pi5B01

Image of CATH 3pi5B02

3pi5B02

CATH Domain 3pi5B02

Image of CATH 3pi5C01

3pi5C01

CATH Domain 3pi5C01

Image of CATH 3pi5C02

3pi5C02

CATH Domain 3pi5C02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	28 Mar, 2011	Chopped
B	28 Mar, 2011	Chopped
C	28 Mar, 2011	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3pi5A01	01 Apr, 2011	2.40.70.10	Assigned
3pi5A02	01 Apr, 2011	2.40.70.10	Assigned
3pi5B01	01 Apr, 2011	2.40.70.10	Assigned
3pi5B02	01 Apr, 2011	2.40.70.10	Assigned
3pi5C01	01 Apr, 2011	2.40.70.10	Assigned
3pi5C02	01 Apr, 2011	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1