PDB 3n4l

PDB Links
Overview

PDB Information

PDB	3N4L
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents. Truong, A.P., Probst, G.D., Aquino, J., Fang, L., Brogley, L., Sealy, J.M., Hom, R.K., Tucker, J.A., John, V., Tung, J.S., Pleiss, M.A., Konradi, A.W., Sham, H.L., Dappen, M.S., Toth, G., Yao, N., Brecht, E., Pan, H., Artis, D.R., Ruslim, L., Bova, M.P., Sinha, S., Yednock, T.A., Zmolek, W., Quinn, K.P., Sauer, J.M. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2010-05-21
Resolution	2.700
CATH Insert Date	23 Jan, 2011

PDB Images (10)

Image of CATH 3n4l

3n4l

PDB 3n4l

Image of CATH 3n4lA

3n4lA

PDB Chain 3n4lA

Image of CATH 3n4lB

3n4lB

PDB Chain 3n4lB

Image of CATH 3n4lC

3n4lC

PDB Chain 3n4lC

Image of CATH 3n4lA01

3n4lA01

CATH Domain 3n4lA01

Image of CATH 3n4lA02

3n4lA02

CATH Domain 3n4lA02

Image of CATH 3n4lB01

3n4lB01

CATH Domain 3n4lB01

Image of CATH 3n4lB02

3n4lB02

CATH Domain 3n4lB02

Image of CATH 3n4lC01

3n4lC01

CATH Domain 3n4lC01

Image of CATH 3n4lC02

3n4lC02

CATH Domain 3n4lC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	24 Jan, 2011	Chopped
B	24 Jan, 2011	Chopped
C	24 Jan, 2011	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3n4lA01	17 Feb, 2011	2.40.70.10	Assigned
3n4lA02	17 Feb, 2011	2.40.70.10	Assigned
3n4lB01	17 Feb, 2011	2.40.70.10	Assigned
3n4lB02	17 Feb, 2011	2.40.70.10	Assigned
3n4lC01	17 Feb, 2011	2.40.70.10	Assigned
3n4lC02	17 Feb, 2011	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1