PDB 3ly2

PDB Links
Overview

PDB Information

PDB	3LY2
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Water-soluble PDE4 inhibitors for the treatment of dry eye. Govek, S.P., Oshiro, G., Anzola, J.V., Beauregard, C., Chen, J., Coyle, A.R., Gamache, D.A., Hellberg, M.R., Hsien, J.N., Lerch, J.M., Liao, J.C., Malecha, J.W., Staszewski, L.M., Thomas, D.J., Yanni, J.M., Noble, S.A., Shiau, A.K. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2010-02-26
Resolution	2.600
CATH Insert Date	02 May, 2010

PDB Images (17)

3ly2

PDB 3ly2

3ly2A

PDB Chain 3ly2A

3ly2B

PDB Chain 3ly2B

3ly2C

PDB Chain 3ly2C

3ly2D

PDB Chain 3ly2D

3ly2E

PDB Chain 3ly2E

3ly2F

PDB Chain 3ly2F

3ly2G

PDB Chain 3ly2G

3ly2H

PDB Chain 3ly2H

3ly2A00

CATH Domain 3ly2A00

3ly2B00

CATH Domain 3ly2B00

3ly2C00

CATH Domain 3ly2C00

3ly2D00

CATH Domain 3ly2D00

3ly2E00

CATH Domain 3ly2E00

3ly2F00

CATH Domain 3ly2F00

3ly2G00

CATH Domain 3ly2G00

3ly2H00

CATH Domain 3ly2H00

PDB Prints

PDB Chains (8)

Chain ID	Date inserted into CATH	CATH Status
A	03 May, 2010	Chopped
B	03 May, 2010	Chopped
C	03 May, 2010	Chopped
D	03 May, 2010	Chopped
E	03 May, 2010	Chopped
F	03 May, 2010	Chopped
G	03 May, 2010	Chopped
H	03 May, 2010	Chopped

CATH Domains (8)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3ly2A00	25 Apr, 2013	1.10.1300.10	Assigned
3ly2B00	25 Apr, 2013	1.10.1300.10	Assigned
3ly2C00	25 Apr, 2013	1.10.1300.10	Assigned
3ly2D00	25 Apr, 2013	1.10.1300.10	Assigned
3ly2E00	25 Apr, 2013	1.10.1300.10	Assigned
3ly2F00	25 Apr, 2013	1.10.1300.10	Assigned
3ly2G00	25 Apr, 2013	1.10.1300.10	Assigned
3ly2H00	25 Apr, 2013	1.10.1300.10	Assigned

UniProtKB Entries (8)

Accession	Gene ID	Taxon	Description
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Q07343	PDE4B_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Network disruptions