PDB 3l5e

PDB Information

PDB3L5E
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
Zhu, Z., Sun, Z.Y., Ye, Y., Voigt, J., Strickland, C., Smith, E.M., Cumming, J., Wang, L., Wong, J., Wang, Y.S., Wyss, D.F., Chen, X., Kuvelkar, R., Kennedy, M.E., Favreau, L., Parker, E., McKittrick, B.A., Stamford, A., Czarniecki, M., Greenlee, W., Hunter, J.C.
J.Med.Chem.
HeaderHydrolase
Released2009-12-21
Resolution1.530
CATH Insert Date18 Feb, 2010

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 18 Feb, 2010 Chopped
B 18 Feb, 2010 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3l5eA01 03 Jul, 2010 2.40.70.10 Assigned
3l5eA02 03 Jul, 2010 2.40.70.10 Assigned
3l5eB01 03 Jul, 2010 2.40.70.10 Assigned
3l5eB02 03 Jul, 2010 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1