Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.
Sutherlin, D.P., Sampath, D., Berry, M., Castanedo, G., Chang, Z., Chuckowree, I., Dotson, J., Folkes, A., Friedman, L., Goldsmith, R., Heffron, T., Lee, L., Lesnick, J., Lewis, C., Mathieu, S., Nonomiya, J., Olivero, A., Pang, J., Prior, W.W., Salphati, L., Sideris, S., Tian, Q., Tsui, V., Wan, N.C., Wang, S., Wiesmann, C., Wong, S., Zhu, B.Y.
J.Med.Chem.