Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease
Becker, D.P., Barta, T.E., Bedell, L.J., Boehm, T.L., Bond, B.R., Carroll, J., Carron, C.P., Decrescenzo, G.A., Easton, A.M., Freskos, J.N., Funckes-Shippy, C.L., Heron, M., Hockerman, S., Howard, C.P., Kiefer, J.R., Li, M.H., Mathis, K.J., McDonald, J.J., Mehta, P.P., Munie, G.E., Sunyer, T., Swearingen, C.A., Villamil, C.I., Welsch, D., Williams, J.M., Yu, Y., Yao, J.
J.Med.Chem.