PDB 3krj

PDB Information

PDB3KRJ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
Illig, C.R., Manthey, C.L., Wall, M.J., Meegalla, S.K., Chen, J., Wilson, K.J., Ballentine, S.K., Desjarlais, R.L., Schubert, C., Crysler, C.S., Chen, Y., Molloy, C.J., Chaikin, M.A., Donatelli, R.R., Yurkow, E., Zhou, Z., Player, M.R., Tomczuk, B.E.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2009-11-18
Resolution2.100
CATH Insert Date23 Jan, 2011

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 24 Jan, 2011 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
3krjA01 17 Feb, 2011 3.30.200.20 Assigned
3krjA02 17 Feb, 2011 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P07333 CSF1R_HUMAN Homo sapiens Macrophage colony-stimulating factor 1 receptor
P11362 FGFR1_HUMAN Homo sapiens Fibroblast growth factor receptor 1