PDB 3kc3

PDB Links
Overview

PDB Information

PDB	3KC3
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. Argiriadi, M.A., Ericsson, A.M., Harris, C.M., Banach, D.L., Borhani, D.W., Calderwood, D.J., Demers, M.D., Dimauro, J., Dixon, R.W., Hardman, J., Kwak, S., Li, B., Mankovich, J.A., Marcotte, D., Mullen, K.D., Ni, B., Pietras, M., Sadhukhan, R., Sousa, S., Tomlinson, M.J., Wang, L., Xiang, T., Talanian, R.V. Bioorg.Med.Chem.Lett.
Header	Transferase
Released	2009-10-20
Resolution	2.900
CATH Insert Date	14 Jan, 2010

PDB Images (37)

3kc3

PDB 3kc3

3kc3A

PDB Chain 3kc3A

3kc3B

PDB Chain 3kc3B

3kc3C

PDB Chain 3kc3C

3kc3D

PDB Chain 3kc3D

3kc3E

PDB Chain 3kc3E

3kc3F

PDB Chain 3kc3F

3kc3G

PDB Chain 3kc3G

3kc3H

PDB Chain 3kc3H

3kc3I

PDB Chain 3kc3I

3kc3J

PDB Chain 3kc3J

3kc3K

PDB Chain 3kc3K

3kc3L

PDB Chain 3kc3L

3kc3A01

CATH Domain 3kc3A01

3kc3A02

CATH Domain 3kc3A02

3kc3B01

CATH Domain 3kc3B01

3kc3B02

CATH Domain 3kc3B02

3kc3C01

CATH Domain 3kc3C01

3kc3C02

CATH Domain 3kc3C02

3kc3D01

CATH Domain 3kc3D01

3kc3D02

CATH Domain 3kc3D02

3kc3E01

CATH Domain 3kc3E01

3kc3E02

CATH Domain 3kc3E02

3kc3F01

CATH Domain 3kc3F01

3kc3F02

CATH Domain 3kc3F02

3kc3G01

CATH Domain 3kc3G01

3kc3G02

CATH Domain 3kc3G02

3kc3H01

CATH Domain 3kc3H01

3kc3H02

CATH Domain 3kc3H02

3kc3I01

CATH Domain 3kc3I01

3kc3I02

CATH Domain 3kc3I02

3kc3J01

CATH Domain 3kc3J01

3kc3J02

CATH Domain 3kc3J02

3kc3K01

CATH Domain 3kc3K01

3kc3K02

CATH Domain 3kc3K02

3kc3L01

CATH Domain 3kc3L01

3kc3L02

CATH Domain 3kc3L02

PDB Prints

PDB Chains (12)

Chain ID	Date inserted into CATH	CATH Status
A	15 Jan, 2010	Chopped
B	15 Jan, 2010	Chopped
C	15 Jan, 2010	Chopped
D	15 Jan, 2010	Chopped
E	15 Jan, 2010	Chopped
F	15 Jan, 2010	Chopped
G	15 Jan, 2010	Chopped
H	15 Jan, 2010	Chopped
I	15 Jan, 2010	Chopped
J	15 Jan, 2010	Chopped
K	15 Jan, 2010	Chopped
L	15 Jan, 2010	Chopped

CATH Domains (24)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3kc3A01	15 Apr, 2010	3.30.200.20	Assigned
3kc3A02	15 Apr, 2010	1.10.510.10	Assigned
3kc3B01	16 Apr, 2010	3.30.200.20	Assigned
3kc3B02	16 Apr, 2010	1.10.510.10	Assigned
3kc3C01	16 Apr, 2010	3.30.200.20	Assigned
3kc3C02	16 Apr, 2010	1.10.510.10	Assigned
3kc3D01	15 Apr, 2010	3.30.200.20	Assigned
3kc3D02	15 Apr, 2010	1.10.510.10	Assigned
3kc3E01	15 Apr, 2010	3.30.200.20	Assigned
3kc3E02	15 Apr, 2010	1.10.510.10	Assigned
3kc3F01	16 Apr, 2010	3.30.200.20	Assigned
3kc3F02	16 Apr, 2010	1.10.510.10	Assigned
3kc3G01	16 Apr, 2010	3.30.200.20	Assigned
3kc3G02	16 Apr, 2010	1.10.510.10	Assigned
3kc3H01	15 Apr, 2010	3.30.200.20	Assigned
3kc3H02	15 Apr, 2010	1.10.510.10	Assigned
3kc3I01	15 Apr, 2010	3.30.200.20	Assigned
3kc3I02	15 Apr, 2010	1.10.510.10	Assigned
3kc3J01	15 Apr, 2010	3.30.200.20	Assigned
3kc3J02	15 Apr, 2010	1.10.510.10	Assigned
3kc3K01	15 Apr, 2010	3.30.200.20	Assigned
3kc3K02	15 Apr, 2010	1.10.510.10	Assigned
3kc3L01	15 Apr, 2010	3.30.200.20	Assigned
3kc3L02	15 Apr, 2010	1.10.510.10	Assigned

UniProtKB Entries (12)

Accession	Gene ID	Taxon	Description
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2
P49137	MAPK2_HUMAN	Homo sapiens	MAP kinase-activated protein kinase 2