PDB 3k5c

PDB Links
Overview

PDB Information

PDB	3K5C
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Lerchner, A., Machauer, R., Betschart, C., Veenstra, S., Rueeger, H., McCarthy, C., Tintelnot-Blomley, M., Jaton, A.L., Rabe, S., Desrayaud, S., Enz, A., Staufenbiel, M., Paganetti, P., Rondeau, J.M., Neumann, U. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2009-10-07
Resolution	2.120
CATH Insert Date	04 Mar, 2010

PDB Images (10)

Image of CATH 3k5c

3k5c

PDB 3k5c

Image of CATH 3k5cA

3k5cA

PDB Chain 3k5cA

Image of CATH 3k5cB

3k5cB

PDB Chain 3k5cB

Image of CATH 3k5cC

3k5cC

PDB Chain 3k5cC

Image of CATH 3k5cA01

3k5cA01

CATH Domain 3k5cA01

Image of CATH 3k5cA02

3k5cA02

CATH Domain 3k5cA02

Image of CATH 3k5cB01

3k5cB01

CATH Domain 3k5cB01

Image of CATH 3k5cB02

3k5cB02

CATH Domain 3k5cB02

Image of CATH 3k5cC01

3k5cC01

CATH Domain 3k5cC01

Image of CATH 3k5cC02

3k5cC02

CATH Domain 3k5cC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	05 Mar, 2010	Chopped
B	05 Mar, 2010	Chopped
C	05 Mar, 2010	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3k5cA01	12 Apr, 2010	2.40.70.10	Assigned
3k5cA02	12 Apr, 2010	2.40.70.10	Assigned
3k5cB01	12 Apr, 2010	2.40.70.10	Assigned
3k5cB02	12 Apr, 2010	2.40.70.10	Assigned
3k5cC01	12 Apr, 2010	2.40.70.10	Assigned
3k5cC02	12 Apr, 2010	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1