PDB 3jsi

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Overview

PDB Information

PDB	3JSI
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy. Verhoest, P.R., Proulx-Lafrance, C., Corman, M., Chenard, L., Helal, C.J., Hou, X., Kleiman, R., Liu, S., Marr, E., Menniti, F.S., Schmidt, C.J., Vanase-Frawley, M., Schmidt, A.W., Williams, R.D., Nelson, F.R., Fonseca, K.R., Liras, S. J.Med.Chem.
Header	Hydrolase
Released	2009-09-10
Resolution	2.720
CATH Insert Date	03 Dec, 2009

PDB Images (5)

Image of CATH 3jsi

3jsi

PDB 3jsi

Image of CATH 3jsiA

3jsiA

PDB Chain 3jsiA

Image of CATH 3jsiB

3jsiB

PDB Chain 3jsiB

Image of CATH 3jsiA00

3jsiA00

CATH Domain 3jsiA00

Image of CATH 3jsiB00

3jsiB00

CATH Domain 3jsiB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	03 Dec, 2009	Chopped
B	03 Dec, 2009	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3jsiA00	08 Apr, 2010	1.10.1300.10	Assigned
3jsiB00	08 Apr, 2010	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O76083	PDE9A_HUMAN	Homo sapiens	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
O76083	PDE9A_HUMAN	Homo sapiens	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A