PDB 3i25

PDB Information

PDB3I25
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core
Bjorklund, C., Adolfsson, H., Jansson, K., Lindberg, J., Vrang, L., Hallberg, A., Rosenquist, A., Samuelsson, B.
Bioorg.Med.Chem.
HeaderHydrolase
Released2009-06-29
Resolution2.100
CATH Insert Date06 Jun, 2010

PDB Images (10)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 06 Jun, 2010 Chopped
B 06 Jun, 2010 Chopped
C 06 Jun, 2010 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
3i25A01 10 Jun, 2010 2.40.70.10 Assigned
3i25A02 10 Jun, 2010 2.40.70.10 Assigned
3i25B01 10 Jun, 2010 2.40.70.10 Assigned
3i25B02 10 Jun, 2010 2.40.70.10 Assigned
3i25C01 10 Jun, 2010 2.40.70.10 Assigned
3i25C02 10 Jun, 2010 2.40.70.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1