PDB 3drs

PDB Information

PDB3DRS
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHuman immunodeficiency virus type 1
Primary Citation
Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses.
Tucker, T.J., Sisko, J.T., Tynebor, R.M., Williams, T.M., Felock, P.J., Flynn, J.A., Lai, M.T., Liang, Y., McGaughey, G., Liu, M., Miller, M., Moyer, G., Munshi, V., Perlow-Poehnelt, R., Prasad, S., Reid, J.C., Sanchez, R., Torrent, M., Vacca, J.P., Wan, B.L., Yan, Y.
J.Med.Chem.
HeaderTransferase
Released2008-07-11
Resolution3.150
CATH Insert Date16 Oct, 2008

PDB Images (12)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 16 Oct, 2008 Chopped
B 16 Oct, 2008 Chopped

CATH Domains (9)

Domain ID Date inserted into CATH Superfamily CATH Status
3drsA01 17 Oct, 2008 3.10.10.10 Assigned
3drsA02 17 Oct, 2008 3.30.70.270 Assigned
3drsA03 17 Oct, 2008 3.30.70.270 Assigned
3drsA04 17 Oct, 2008 3.30.70.270 Assigned
3drsA05 17 Oct, 2008 3.30.420.10 Assigned
3drsB01 17 Oct, 2008 3.10.10.10 Assigned
3drsB02 17 Oct, 2008 3.30.70.270 Assigned
3drsB03 17 Oct, 2008 3.30.70.270 Assigned
3drsB04 17 Oct, 2008 3.30.70.270 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein