PDB 3drp

PDB Information

PDB3DRP
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHuman immunodeficiency virus type 1
Primary Citation
Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses.
Tucker, T.J., Sisko, J.T., Tynebor, R.M., Williams, T.M., Felock, P.J., Flynn, J.A., Lai, M.T., Liang, Y., McGaughey, G., Liu, M., Miller, M., Moyer, G., Munshi, V., Perlow-Poehnelt, R., Prasad, S., Reid, J.C., Sanchez, R., Torrent, M., Vacca, J.P., Wan, B.L., Yan, Y.
J.Med.Chem.
HeaderTransferase
Released2008-07-11
Resolution2.600
CATH Insert Date16 Oct, 2008

PDB Images (12)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 16 Oct, 2008 Chopped
B 16 Oct, 2008 Chopped

CATH Domains (9)

Domain ID Date inserted into CATH Superfamily CATH Status
3drpA01 17 Oct, 2008 3.10.10.10 Assigned
3drpA02 17 Oct, 2008 3.30.70.270 Assigned
3drpA03 17 Oct, 2008 3.30.70.270 Assigned
3drpA04 17 Oct, 2008 3.30.70.270 Assigned
3drpA05 17 Oct, 2008 3.30.420.10 Assigned
3drpB01 17 Oct, 2008 3.10.10.10 Assigned
3drpB02 17 Oct, 2008 3.30.70.270 Assigned
3drpB03 17 Oct, 2008 3.30.70.270 Assigned
3drpB04 17 Oct, 2008 3.30.70.270 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein