PDB 3c6u

PDB Information

PDB3C6U
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHIV-1 M:B_HXB2R
Primary Citation
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Tucker, T.J., Saggar, S., Sisko, J.T., Tynebor, R.M., Williams, T.M., Felock, P.J., Flynn, J.A., Lai, M.T., Liang, Y., McGaughey, G., Liu, M., Miller, M., Moyer, G., Munshi, V., Perlow-Poehnelt, R., Prasad, S., Sanchez, R., Torrent, M., Vacca, J.P., Wan, B.L., Yan, Y.
Bioorg.Med.Chem.Lett.
HeaderTransferase
Released2008-02-05
Resolution2.700
CATH Insert Date27 Apr, 2008

PDB Images (12)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 27 Apr, 2008 Chopped
B 27 Apr, 2008 Chopped

CATH Domains (9)

Domain ID Date inserted into CATH Superfamily CATH Status
3c6uA01 28 Apr, 2008 3.10.10.10 Assigned
3c6uA02 28 Apr, 2008 3.30.70.270 Assigned
3c6uA03 28 Apr, 2008 3.30.70.270 Assigned
3c6uA04 28 Apr, 2008 3.30.70.270 Assigned
3c6uA05 28 Apr, 2008 3.30.420.10 Assigned
3c6uB01 28 Apr, 2008 3.10.10.10 Assigned
3c6uB02 28 Apr, 2008 3.30.70.270 Assigned
3c6uB03 28 Apr, 2008 3.30.70.270 Assigned
3c6uB04 28 Apr, 2008 3.30.70.270 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein