PDB 2yhi

PDB Information

PDB2YHI
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceTRYPANOSOMA BRUCEI
Primary Citation
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
Linciano, P., Dawson, A., Pohner, I., Costa, D.M., Sa, M.S., Cordeiro-da-Silva, A., Luciani, R., Gul, S., Witt, G., Ellinger, B., Kuzikov, M., Gribbon, P., Reinshagen, J., Wolf, M., Behrens, B., Hannaert, V., Michels, P.A.M., Nerini, E., Pozzi, C., di Pisa, F., Landi, G., Santarem, N., Ferrari, S., Saxena, P., Lazzari, S., Cannazza, G., Freitas-Junior, L.H., Moraes, C.B., Pascoalino, B.S., Alcantara, L.M., Bertolacini, C.P., Fontana, V., Wittig, U., Muller, W., Wade, R.C., Hunter, W.N., Mangani, S., Costantino, L., Costi, M.P.
ACS Omega
HeaderOxidoreductase
Released2011-05-03
Resolution1.800
CATH Insert Date27 May, 2012

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 28 May, 2012 Chopped
B 28 May, 2012 Chopped
C 28 May, 2012 Chopped
D 28 May, 2012 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
2yhiA00 14 Nov, 2012 3.40.50.720 Assigned
2yhiB00 14 Nov, 2012 3.40.50.720 Assigned
2yhiC00 14 Nov, 2012 3.40.50.720 Assigned
2yhiD00 14 Nov, 2012 3.40.50.720 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei TREU927 Pteridine reductase, putative
Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei TREU927 Pteridine reductase, putative
Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei TREU927 Pteridine reductase, putative
Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei TREU927 Pteridine reductase, putative