PDB Information

PDB2XXI
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceRATTUS NORVEGICUS
Primary Citation
Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of Ampa Receptor Positive Allosteric Modulators.
Ward, S.E., Harries, M., Aldegheri, L., Austin, N.E., Ballantine, S., Ballini, E., Bradley, D.M., Bax, B.D., Clarke, B.P., Harris, A.J., Harrison, S.A., Melarange, R.A., Mookherjee, C., Mosley, J., Dal Negro, G., Oliosi, B., Smith, K.J., Thewlis, K.M., Woollard, P.M., Yusaf, S.P.
J.Med.Chem.
HeaderTransport Protein
Released2010-11-10
Resolution1.600
CATH Insert Date10 Apr, 2011

PDB Images (10)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2011 Chopped
B 11 Apr, 2011 Chopped
C 11 Apr, 2011 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
2xxiA01 13 Apr, 2011 3.40.190.10 Assigned
2xxiA02 13 Apr, 2011 3.40.190.10 Assigned
2xxiB01 13 Apr, 2011 3.40.190.10 Assigned
2xxiB02 13 Apr, 2011 3.40.190.10 Assigned
2xxiC01 13 Apr, 2011 3.40.190.10 Assigned
2xxiC02 13 Apr, 2011 3.40.190.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P19491 GRIA2_RAT Rattus norvegicus Glutamate receptor 2
P19491 GRIA2_RAT Rattus norvegicus Glutamate receptor 2
P19491 GRIA2_RAT Rattus norvegicus Glutamate receptor 2