PDB 2xa4

PDB Links
Overview

PDB Information

PDB	2XA4
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli BL21(DE3)
Gene Source	Homo sapiens
Primary Citation	Discovery of 5-Chloro-N2-[(1S)-1-(5-Fluoropyrimidin-2-Yl) Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine (Azd1480) as a Novel Inhibitor of the Jak/Stat Pathway Ioannidis, S., Lamb, M.L., Wang, T., Almeida, L., Block, M.H., Davies, A.M., Peng, B., Su, M., Zhang, H., Hoffmann, E., Rivard, C., Green, I., Howard, T., Pollard, H., Read, J., Alimzhanov, M., Bebernitz, G., Bell, K., Ye, M., Huszar, D., Zinda, M. J.Med.Chem.
Header	Transferase
Released	2010-03-26
Resolution	2.040
CATH Insert Date	23 Jan, 2011

PDB Images (7)

Image of CATH 2xa4

2xa4

PDB 2xa4

Image of CATH 2xa4A

2xa4A

PDB Chain 2xa4A

Image of CATH 2xa4B

2xa4B

PDB Chain 2xa4B

Image of CATH 2xa4A01

2xa4A01

CATH Domain 2xa4A01

Image of CATH 2xa4A02

2xa4A02

CATH Domain 2xa4A02

Image of CATH 2xa4B01

2xa4B01

CATH Domain 2xa4B01

Image of CATH 2xa4B02

2xa4B02

CATH Domain 2xa4B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	24 Jan, 2011	Chopped
B	24 Jan, 2011	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
2xa4A01	16 Feb, 2011	3.30.200.20	Assigned
2xa4A02	16 Feb, 2011	1.10.510.10	Assigned
2xa4B01	17 Feb, 2011	3.30.200.20	Assigned
2xa4B02	17 Feb, 2011	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2