PDB Information

PDB2WPA
MethodX-RAY DIFFRACTION
Host OrganismTRICHOPLUSIA NI
Gene SourceHOMO SAPIENS
Primary Citation
Optimization of 6,6-Dimethyl Pyrrolo[3,4-C]Pyrazoles: Identification of Pha-793887, a Potent Cdk Inhibitor Suitable for Intravenous Dosing.
Brasca, M.G., Albanese, C., Alzani, R., Amici, R., Avanzi, N., Ballinari, D., Bischoff, J., Borghi, D., Casale, E., Croci, V., Fiorentini, F., Isacchi, A., Mercurio, C., Nesi, M., Orsini, P., Pastori, W., Pesenti, E., Pevarello, P., Roussel, P., Varasi, M., Volpi, D., Vulpetti, A., Ciomei, M.
Bioorg.Med.Chem.
HeaderCell Cycle
Released2009-08-03
Resolution2.510
CATH Insert Date25 Feb, 2010

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 26 Feb, 2010 Chopped
B 26 Feb, 2010 Chopped
C 26 Feb, 2010 Chopped
D 26 Feb, 2010 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
2wpaA01 02 Mar, 2010 3.30.200.20 Assigned
2wpaA02 02 Mar, 2010 1.10.510.10 Assigned
2wpaB01 02 Mar, 2010 1.10.472.10 Assigned
2wpaB02 02 Mar, 2010 1.10.472.10 Assigned
2wpaC01 02 Mar, 2010 3.30.200.20 Assigned
2wpaC02 02 Mar, 2010 1.10.510.10 Assigned
2wpaD01 02 Mar, 2010 1.10.472.10 Assigned
2wpaD02 02 Mar, 2010 1.10.472.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P24941 CDK2_HUMAN Homo sapiens Cyclin-dependent kinase 2
P20248 CCNA2_HUMAN Homo sapiens Cyclin-A2
P24941 CDK2_HUMAN Homo sapiens Cyclin-dependent kinase 2
P20248 CCNA2_HUMAN Homo sapiens Cyclin-A2