PDB 2wip

PDB Information

PDB2WIP
MethodX-RAY DIFFRACTION
Host OrganismTRICHOPLUSIA NI
Gene SourceHOMO SAPIENS
Primary Citation
Identification of N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline-3-Carboxamide (Pha-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor.
Brasca, M.G., Amboldi, N., Ballinari, D., Cameron, A., Casale, E., Cervi, G., Colombo, M., Colotta, F., Croci, V., D'Alessio, R., Fiorentini, F., Isacchi, A., Mercurio, C., Moretti, W., Panzeri, A., Pastori, W., Pevarello, P., Quartieri, F., Roletto, F., Traquandi, G., Vianello, P., Vulpetti, A., Ciomei, M.
J.Med.Chem.
HeaderTransferase
Released2009-05-14
Resolution2.800
CATH Insert Date16 Aug, 2009

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 16 Aug, 2009 Chopped
B 16 Aug, 2009 Chopped
C 16 Aug, 2009 Chopped
D 16 Aug, 2009 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
2wipA01 28 Aug, 2009 3.30.200.20 Assigned
2wipA02 28 Aug, 2009 1.10.510.10 Assigned
2wipB01 28 Aug, 2009 1.10.472.10 Assigned
2wipB02 28 Aug, 2009 1.10.472.10 Assigned
2wipC01 28 Aug, 2009 3.30.200.20 Assigned
2wipC02 28 Aug, 2009 1.10.510.10 Assigned
2wipD01 28 Aug, 2009 1.10.472.10 Assigned
2wipD02 28 Aug, 2009 1.10.472.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P20248 CCNA2_HUMAN Homo sapiens Cyclin-A2
P24941 CDK2_HUMAN Homo sapiens Cyclin-dependent kinase 2
P24941 CDK2_HUMAN Homo sapiens Cyclin-dependent kinase 2
P20248 CCNA2_HUMAN Homo sapiens Cyclin-A2