PDB Information

PDB2WC0
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceHOMO SAPIENS
Primary Citation
Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.J.
J.Biol.Chem.
HeaderHydrolase/Hormone
Released2009-03-06
Resolution2.800
CATH Insert Date16 Aug, 2009

PDB Images (15)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 16 Aug, 2009 Chopped
B 16 Aug, 2009 Chopped
C 16 Aug, 2009 Rejected
D 16 Aug, 2009 Rejected
E 16 Aug, 2009 Rejected
F 16 Aug, 2009 Rejected

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
2wc0A01 30 Aug, 2013 3.30.830.10 Assigned
2wc0A02 30 Aug, 2013 3.30.830.10 Assigned
2wc0A03 30 Aug, 2013 3.30.830.10 Assigned
2wc0A04 30 Aug, 2013 3.30.830.10 Assigned
2wc0B01 30 Aug, 2013 3.30.830.10 Assigned
2wc0B02 30 Aug, 2013 3.30.830.10 Assigned
2wc0B03 30 Aug, 2013 3.30.830.10 Assigned
2wc0B04 30 Aug, 2013 3.30.830.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P01308 INS_HUMAN Homo sapiens Insulin
P01308 INS_HUMAN Homo sapiens Insulin
P14735 IDE_HUMAN Homo sapiens Insulin-degrading enzyme
P14735 IDE_HUMAN Homo sapiens Insulin-degrading enzyme
P01308 INS_HUMAN Homo sapiens Insulin
P01308 INS_HUMAN Homo sapiens Insulin