PDB 2q15

PDB Information

PDB2Q15
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
Baxter, E.W., Conway, K.A., Kennis, L., Bischoff, F., Mercken, M.H., Winter, H.L., Reynolds, C.H., Tounge, B.A., Luo, C., Scott, M.K., Huang, Y., Braeken, M., Pieters, S.M., Berthelot, D.J., Masure, S., Bruinzeel, W.D., Jordan, A.D., Parker, M.H., Boyd, R.E., Qu, J., Alexander, R.S., Brenneman, D.E., Reitz, A.B.
J.Med.Chem.
HeaderHydrolase
Released2007-05-23
Resolution2.400
CATH Insert Date07 Nov, 2007

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Nov, 2007 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
2q15A01 23 Nov, 2007 2.40.70.10 Assigned
2q15A02 23 Nov, 2007 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1