PDB 2q11

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Overview

PDB Information

PDB	2Q11
Method	X-RAY DIFFRACTION
Host Organism	unidentified baculovirus
Gene Source	Homo sapiens
Primary Citation	2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. Baxter, E.W., Conway, K.A., Kennis, L., Bischoff, F., Mercken, M.H., Winter, H.L., Reynolds, C.H., Tounge, B.A., Luo, C., Scott, M.K., Huang, Y., Braeken, M., Pieters, S.M., Berthelot, D.J., Masure, S., Bruinzeel, W.D., Jordan, A.D., Parker, M.H., Boyd, R.E., Qu, J., Alexander, R.S., Brenneman, D.E., Reitz, A.B. J.Med.Chem.
Header	Hydrolase
Released	2007-05-23
Resolution	2.400
CATH Insert Date	07 Nov, 2007

PDB Images (10)

Image of CATH 2q11

2q11

PDB 2q11

Image of CATH 2q11A

2q11A

PDB Chain 2q11A

Image of CATH 2q11B

2q11B

PDB Chain 2q11B

Image of CATH 2q11C

2q11C

PDB Chain 2q11C

Image of CATH 2q11A01

2q11A01

CATH Domain 2q11A01

Image of CATH 2q11A02

2q11A02

CATH Domain 2q11A02

Image of CATH 2q11B01

2q11B01

CATH Domain 2q11B01

Image of CATH 2q11B02

2q11B02

CATH Domain 2q11B02

Image of CATH 2q11C01

2q11C01

CATH Domain 2q11C01

Image of CATH 2q11C02

2q11C02

CATH Domain 2q11C02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	08 Nov, 2007	Chopped
B	08 Nov, 2007	Chopped
C	08 Nov, 2007	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
2q11A01	23 Nov, 2007	2.40.70.10	Assigned
2q11A02	23 Nov, 2007	2.40.70.10	Assigned
2q11B01	23 Nov, 2007	2.40.70.10	Assigned
2q11B02	23 Nov, 2007	2.40.70.10	Assigned
2q11C01	23 Nov, 2007	2.40.70.10	Assigned
2q11C02	23 Nov, 2007	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1