PDB 2p4j

PDB Information

PDB2P4J
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21
Gene SourceHomo sapiens
Primary Citation
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
Ghosh, A.K., Kumaragurubaran, N., Hong, L., Kulkarni, S.S., Xu, X., Chang, W., Weerasena, V., Turner, R., Koelsch, G., Bilcer, G., Tang, J.
J.Med.Chem.
HeaderHydrolase
Released2007-03-12
Resolution2.500
CATH Insert Date26 Jul, 2007

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 26 Jul, 2007 Chopped
B 26 Jul, 2007 Chopped
C 26 Jul, 2007 Chopped
D 26 Jul, 2007 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
2p4jA01 16 Aug, 2007 2.40.70.10 Assigned
2p4jA02 16 Aug, 2007 2.40.70.10 Assigned
2p4jB01 16 Aug, 2007 2.40.70.10 Assigned
2p4jB02 16 Aug, 2007 2.40.70.10 Assigned
2p4jC01 16 Aug, 2007 2.40.70.10 Assigned
2p4jC02 16 Aug, 2007 2.40.70.10 Assigned
2p4jD01 16 Aug, 2007 2.40.70.10 Assigned
2p4jD02 16 Aug, 2007 2.40.70.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1