PDB 2i78

PDB Information

PDB2I78
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of Cyclohexene-constrained Phenethylamine ABT-341, a Highly Potent, Selective, Orally Bioavailable, Safe and Potential Next-generation Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Pei, Z., Li, X., vonGeldern, T.W., Madar, D.J., L Longenecker, K., Yong, H., Lubben, T.H., Stewart, K.D., Zinker, B.A., Backes, B.J., Judd, A.S., Mulhern, M., Ballaron, S.J., Stashko, M.A., Mika, A.K., Beno, D.W.A., Reinhart, G.A., Fryer, R.M., Preusser, L.C., Kempf-Grote, A.J., Sham, H.L., Trevillyan, J.M.
To be Published
HeaderHydrolase
Released2006-08-30
Resolution2.500
CATH Insert Date07 Nov, 2007

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 Nov, 2007 Chopped
B 08 Nov, 2007 Chopped
C 08 Nov, 2007 Chopped
D 08 Nov, 2007 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
2i78A01 23 Nov, 2007 3.40.50.1820 Assigned
2i78A02 23 Nov, 2007 2.140.10.30 Assigned
2i78B01 23 Nov, 2007 3.40.50.1820 Assigned
2i78B02 23 Nov, 2007 2.140.10.30 Assigned
2i78C01 23 Nov, 2007 3.40.50.1820 Assigned
2i78C02 23 Nov, 2007 2.140.10.30 Assigned
2i78D01 23 Nov, 2007 3.40.50.1820 Assigned
2i78D02 23 Nov, 2007 2.140.10.30 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4