PDB 1tl8

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

PDB Links
Overview

PDB Information

PDB	1TL8
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis Ioanoviciu, A., Antony, S., Pommier, Y., Staker, B.L., Stewart, L., Cushman, M. J.Med.Chem.
Header	Isomerase/Dna
Released	2004-06-09
Resolution	3.100
CATH Insert Date	05 Mar, 2006

PDB Images (9)

Image of CATH 1tl8

1tl8

PDB 1tl8

Image of CATH 1tl8A

1tl8A

PDB Chain 1tl8A

Image of CATH 1tl8B

1tl8B

PDB Chain 1tl8B

Image of CATH 1tl8C

1tl8C

PDB Chain 1tl8C

Image of CATH 1tl8D

1tl8D

PDB Chain 1tl8D

Image of CATH 1tl8A01

1tl8A01

CATH Domain 1tl8A01

Image of CATH 1tl8A02

1tl8A02

CATH Domain 1tl8A02

Image of CATH 1tl8A03

1tl8A03

CATH Domain 1tl8A03

Image of CATH 1tl8A04

1tl8A04

CATH Domain 1tl8A04

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	05 Mar, 2006	Chopped
B	15 Mar, 2006	Rejected
C	15 Mar, 2006	Rejected
D	15 Mar, 2006	Rejected

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
1tl8A01	09 Mar, 2006	2.170.11.10	Assigned
1tl8A02	09 Mar, 2006	1.10.10.41	Assigned
1tl8A03	09 Mar, 2006	3.90.15.10	Assigned
1tl8A04	09 Mar, 2006	1.10.132.10	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
P11387	TOP1_HUMAN	Homo sapiens	DNA topoisomerase 1