PDB Information

PDB1TL8
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis
Ioanoviciu, A., Antony, S., Pommier, Y., Staker, B.L., Stewart, L., Cushman, M.
J.Med.Chem.
HeaderIsomerase/Dna
Released2004-06-09
Resolution3.100
CATH Insert Date05 Mar, 2006

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Mar, 2006 Chopped
B 15 Mar, 2006 Rejected
C 15 Mar, 2006 Rejected
D 15 Mar, 2006 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
1tl8A01 09 Mar, 2006 2.170.11.10 Assigned
1tl8A02 09 Mar, 2006 1.10.10.41 Assigned
1tl8A03 09 Mar, 2006 3.90.15.10 Assigned
1tl8A04 09 Mar, 2006 1.10.132.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P11387 TOP1_HUMAN Homo sapiens DNA topoisomerase 1