PDB Information

PDB1SA4
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity.
Reid, T.S., Beese, L.S.
Biochemistry
HeaderTransferase
Released2004-02-06
Resolution2.100
CATH Insert Date05 Mar, 2006

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Mar, 2006 Chopped
B 05 Mar, 2006 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
1sa4A00 05 Mar, 2006 1.25.40.120 Assigned
1sa4B00 05 Mar, 2006 1.50.10.20 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P49356 FNTB_HUMAN Homo sapiens Protein farnesyltransferase subunit beta
P49354 FNTA_HUMAN Homo sapiens Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha